dc.contributor.author |
M J Akhtar |
|
dc.contributor.author |
M Hafiz |
|
dc.contributor.author |
S Khan |
|
dc.date.accessioned |
2023-01-23T09:50:16Z |
|
dc.date.available |
2023-01-23T09:50:16Z |
|
dc.date.issued |
1993-01-05 |
|
dc.identifier.citation |
Akhtar, M. J., Khan, S., & Hafiz, M. (1994). High-performance liquid chromatographic assay for the determination of paracetamol, pseudoephedrine hydrochloride and triprolidine hydrochloride. Journal of pharmaceutical and biomedical analysis, 12(3), 379-382. |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/16641 |
|
dc.description.abstract |
The different UV absorption characteristics of paracetamol, pseudoephedrine hydrochloride and triprolidine hydrochloride have been used to facilitate their determination in pharmaceutical preparations by HPLC. The method developed involves isocratic, reversed-phase chromatography. A 'wavelength switching' programme is preferred to the use of a compromise wavelength for all three compounds. This gives reasonable UV responses despite widely different UV characteristics and concentrations of drugs. The limits of quantitation are found to be within 200-700 micrograms ml-1 for paracetamol, 24-84 micrograms ml-1 for pseudoephedrine HCl and 1.0-4.0 micrograms ml-1 for triprolidine HCl. The method performs well in terms of precision and accuracy as indicated by linear regression analysis. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
en_US |
dc.title |
High-performance liquid chromatographic assay for the determination of paracetamol, pseudoephedrine hydrochloride and triprolidine hydrochloride |
en_US |
dc.type |
Article |
en_US |