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High-performance liquid chromatographic assay for the determination of paracetamol, pseudoephedrine hydrochloride and triprolidine hydrochloride

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dc.contributor.author M J Akhtar
dc.contributor.author M Hafiz
dc.contributor.author S Khan
dc.date.accessioned 2023-01-23T09:50:16Z
dc.date.available 2023-01-23T09:50:16Z
dc.date.issued 1993-01-05
dc.identifier.citation Akhtar, M. J., Khan, S., & Hafiz, M. (1994). High-performance liquid chromatographic assay for the determination of paracetamol, pseudoephedrine hydrochloride and triprolidine hydrochloride. Journal of pharmaceutical and biomedical analysis, 12(3), 379-382. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16641
dc.description.abstract The different UV absorption characteristics of paracetamol, pseudoephedrine hydrochloride and triprolidine hydrochloride have been used to facilitate their determination in pharmaceutical preparations by HPLC. The method developed involves isocratic, reversed-phase chromatography. A 'wavelength switching' programme is preferred to the use of a compromise wavelength for all three compounds. This gives reasonable UV responses despite widely different UV characteristics and concentrations of drugs. The limits of quantitation are found to be within 200-700 micrograms ml-1 for paracetamol, 24-84 micrograms ml-1 for pseudoephedrine HCl and 1.0-4.0 micrograms ml-1 for triprolidine HCl. The method performs well in terms of precision and accuracy as indicated by linear regression analysis. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.title High-performance liquid chromatographic assay for the determination of paracetamol, pseudoephedrine hydrochloride and triprolidine hydrochloride en_US
dc.type Article en_US


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