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Serotonergic neurotransmission in the regulation of appetite: a receptor approach

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dc.contributor.author D J Haleem
dc.date.accessioned 2023-01-23T10:17:30Z
dc.date.available 2023-01-23T10:17:30Z
dc.date.issued 1993-01-12
dc.identifier.citation Haleem, D. J. (1993). Serotonergic neurotransmission in the regulation of appetite: a receptor approach. Pakistan journal of pharmaceutical sciences, 6(1), 89-96. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16648
dc.description.abstract Neurochemical research on brain 5-hydroxytryptamine (5-HT; serotonin) and feeding shows that rat brain serotonin metabolism is increased following ingestion of a carbohydrate rich diet to generate a neurochemical signal for the termination of meal. Increased metabolism may not necessarily enhance postsynaptic function; neuropharmacological studies therefore gained attention. Drugs which mimick 5-HT function at the post synaptic sites have been shown to decrease feeding in experimental animals. Moreover some 5-HTergic drugs are potent anorectic agents. Multiple receptors for 5-HT exist in the central nervous system. Drugs with selectivity towards 5-HT-1B/ 5-HT-1C sites produced hypophagia, while 5-HT-1A selective drugs increased food intake. Studies designed to investigate sensitivity of these receptors following starvation or satiety may prove useful to develop drugs for therapeutic purposes. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.title Serotonergic neurotransmission in the regulation of appetite: a receptor approach en_US
dc.type Article en_US


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