dc.contributor.author |
D J Haleem |
|
dc.date.accessioned |
2023-01-23T10:17:30Z |
|
dc.date.available |
2023-01-23T10:17:30Z |
|
dc.date.issued |
1993-01-12 |
|
dc.identifier.citation |
Haleem, D. J. (1993). Serotonergic neurotransmission in the regulation of appetite: a receptor approach. Pakistan journal of pharmaceutical sciences, 6(1), 89-96. |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/16648 |
|
dc.description.abstract |
Neurochemical research on brain 5-hydroxytryptamine (5-HT; serotonin) and feeding shows that rat brain serotonin metabolism is increased following ingestion of a carbohydrate rich diet to generate a neurochemical signal for the termination of meal. Increased metabolism may not necessarily enhance postsynaptic function; neuropharmacological studies therefore gained attention. Drugs which mimick 5-HT function at the post synaptic sites have been shown to decrease feeding in experimental animals. Moreover some 5-HTergic drugs are potent anorectic agents. Multiple receptors for 5-HT exist in the central nervous system. Drugs with selectivity towards 5-HT-1B/ 5-HT-1C sites produced hypophagia, while 5-HT-1A selective drugs increased food intake. Studies designed to investigate sensitivity of these receptors following starvation or satiety may prove useful to develop drugs for therapeutic purposes. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
en_US |
dc.title |
Serotonergic neurotransmission in the regulation of appetite: a receptor approach |
en_US |
dc.type |
Article |
en_US |