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EFFECT OF TEMPERATURE AND HUMIDITY ON THE DISINTEGRATION TIME OF PACKAGED PARACETAMOL TABLET FORMULATIONS

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dc.contributor.author IQBAL AHMAD
dc.contributor.author RIAZ HUSSAIN SHAIKH
dc.date.accessioned 2023-01-23T10:17:50Z
dc.date.available 2023-01-23T10:17:50Z
dc.date.issued 1994-01-01
dc.identifier.citation Ahmad, I., & Shaikh, R. H. (1994). Effect of temperature and humidity on the disintegration time of packaged paracetamol tablet formulations. Pakistan journal of pharmaceutical sciences, 7(1), 1-7. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16649
dc.description.abstract A study of the effect of various temperature and humidity conditions on the disintegration time of different brands of packaged paracetamol tablet formulations has been made over a period of six months. Under all the storage conditions paracetamol tablets show an increase in disintegration time ranging from 9.1 to 65.5% (200 mg tablets) and 1.2 to 150.0% (500 mg tablets) on increasing the temperature from 25 to 45°C (75% RH). The increase in disintegration time on increasing the temperature from 25 to 45°C (M)% RH) ranges from 14.3 to 157.7% (200 mg tablets) and 15.3 to 92.3% (500 mg tablets). The overall increase in disintegration time from 25-45o C at 75% and 100% RH is 36.4 to 56.4° (201 mg tablets) and 10.0 to 1405% (500 mg tablets) and 101.3 to 122.9% (200 mg tablets) and 2.6 to 46.8% (500 mg tablets) respectively. These results indicate that PVC/PVDC/A1 foil packaging cause relatively less change in disintegration time of the tablets compared to that of the polvcoated paper and viscose film. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.title EFFECT OF TEMPERATURE AND HUMIDITY ON THE DISINTEGRATION TIME OF PACKAGED PARACETAMOL TABLET FORMULATIONS en_US
dc.type Article en_US


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