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PRELIMINARY EVALUATION OF ANTINOCICEPTIVE ACTIVITY OF OCIMUM GRATISSIMUM LEAVES

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dc.contributor.author Effraim, K. D.
dc.contributor.author Osunkwo, U.A.
dc.contributor.author Onyeyilli, P.
dc.date.accessioned 2023-03-09T03:58:43Z
dc.date.available 2023-03-09T03:58:43Z
dc.date.issued 1999-07-04
dc.identifier.citation Effraim, K. D., Osunkwo, U. A., & Onyeyilli, P. (1999). Preliminary evaluation of antinociceptive activity of Ocimum gratissimum leaves. PAKISTAN VETERINARY JOURNAL, 19(3), 132-134. en_US
dc.identifier.issn 0253-8313
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/18060
dc.description.abstract The aqueous extract of Ocimurn gratissimum (Linn) leaves was investigated for its possible anti-nociceptive activity. The extract (100 - 800 mgkg') in a dose - dependent fashion significantly (p < 0.005 and p < 0.00051 reduced the number of writhes and stretching induced by 0.6% aqueous solution of acetic acid in Win:1r rats. At a higher dose of 800 tngke. the extract conferred 76.49% protection to the rats as compared with a low (la) mgkg-") dose which conferred 39.19% protection on the rats. The effect of the higher dose in protecting the rats against the acetic acid induced writhing was closer to that of the reference drug Pethidine hydrochloride at a dose of 20 ingke. In the acute toxicity studies, the aqueous extract did not cause any mortality up to a dose at lOg kg''. However, there were clinical signs of loss of appetite, decreased exploratory behaviour, and abnormal body posture, en_US
dc.language.iso en en_US
dc.publisher Faisalabad: Faculty of Veterinary Science University of Agriculture Faisalabad en_US
dc.title PRELIMINARY EVALUATION OF ANTINOCICEPTIVE ACTIVITY OF OCIMUM GRATISSIMUM LEAVES en_US
dc.type Article en_US


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