Abstract:
Kanamycin is an extensively used antibiotic in veterinary practice. Therefore, its disposition kinetics and dosage were investigated in healthy buffalo heifers following a single intramuscular dose of 5 mg/kg body weight. The blood samples collected at proposed time intervals were analyzed for kanamycin concentration by a microbiological assay. Two-compartment model kinetic analysis revealed that the elimination half life (Ph 11) was 4.58 ± 0.75 hours (Mean ± SD). The mean ± SD value of apparent volume of distribution (Vd) was 0.63 ± 0.10 L/kg. Total body clearance (TBC) was 1.67 ± 0.16 ml/min. kg (Mean ± SD). To maintain minimum inhibitory concentration (MIC) of 1.5 pg/ml, the optimum priming and maintenance doses of 6.45 and 5.50 mg/kg body weight, respectively, to be repeated with the dosing interval of 12 hours have been suggested.
