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DISPOSITION KINETICS AND DOSAGE OF KANAMYCIN IN BUFFALO HEIFERS

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dc.contributor.author F. Muhammad
dc.contributor.author M. Nawaz
dc.contributor.author T. Khaliq
dc.contributor.author Javed
dc.date.accessioned 2023-03-09T04:26:31Z
dc.date.available 2023-03-09T04:26:31Z
dc.date.issued 1999-10-08
dc.identifier.citation Muhammad, F., Nawaz, M., Khaliq, T., & Javed, I. (1999). Disposition kinetics and dosage of kanamycin in buffalo heifers. PAKISTAN VETERINARY JOURNAL, 19(4), 197-199. en_US
dc.identifier.issn 0253-8313
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/18088
dc.description.abstract Kanamycin is an extensively used antibiotic in veterinary practice. Therefore, its disposition kinetics and dosage were investigated in healthy buffalo heifers following a single intramuscular dose of 5 mg/kg body weight. The blood samples collected at proposed time intervals were analyzed for kanamycin concentration by a microbiological assay. Two-compartment model kinetic analysis revealed that the elimination half life (Ph 11) was 4.58 ± 0.75 hours (Mean ± SD). The mean ± SD value of apparent volume of distribution (Vd) was 0.63 ± 0.10 L/kg. Total body clearance (TBC) was 1.67 ± 0.16 ml/min. kg (Mean ± SD). To maintain minimum inhibitory concentration (MIC) of 1.5 pg/ml, the optimum priming and maintenance doses of 6.45 and 5.50 mg/kg body weight, respectively, to be repeated with the dosing interval of 12 hours have been suggested. en_US
dc.language.iso en en_US
dc.publisher Faisalabad: Faculty of Veterinary Science University of Agriculture Faisalabad en_US
dc.title DISPOSITION KINETICS AND DOSAGE OF KANAMYCIN IN BUFFALO HEIFERS en_US
dc.type Article en_US


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