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Influence of thyroid volume reduction on absorbed dose in 131I therapy studied by using Geant4 Monte Carlo simulation

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dc.contributor.author Rahman, Ziaur
dc.contributor.author Mirza, Sikander M
dc.contributor.author Arshed, Waheed
dc.contributor.author Mirza, Nasir M
dc.contributor.author Ahmed, Waheed
dc.date.accessioned 2019-11-29T05:09:32Z
dc.date.available 2019-11-29T05:09:32Z
dc.date.issued 2014-01-01
dc.identifier.issn 38 056201
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/1853
dc.description.abstract A simulation study has been performed to quantify the effect of volume reduction on the thyroid absorbed dose per decay and to investigate the variation of energy deposition per decay due to β- and γ-activity of 131I with volume/mass of thyroid, for water, ICRP- and ICRU-soft tissue taken as thyroid material. A Monte Carlo model of the thyroid, in the Geant4 radiation transport simulation toolkit was constructed to compute the β- and γ-absorbed dose in the simulated thyroid phantom for various values of its volume. The effect of the size and shape of the thyroid on energy deposition per decay has also been studied by using spherical, ellipsoidal and cylindrical models for the thyroid and varying its volume in 1–25 cm3 range. The relative differences of Geant4 results for different models with each other and MCNP results lie well below 1.870%. The maximum relative difference among the Geant4 estimated results for water with ICRP and ICRU soft tissues is not more than 0.225%. S-values for ellipsoidal, spherical and cylindrical thyroid models were estimated and the relative difference with published results lies within 3.095%. The absorbed fraction values for beta particles show a good agreement with published values within 2.105% deviation. The Geant4 based simulation results of absorbed fractions for gammas again show a good agreement with the corresponding MCNP and EGS4 results (±6.667%) but have 29.032% higher values than that of MIRD calculated values. Consistent with previous studies, the reduction of the thyroid volume is found to have a substantial effect on the absorbed dose. Geant4 simulations confirm dose dependence on the volume/mass of thyroid in agreement with MCNP and EGS4 computed values but are substantially different from MIRD8 data. Therefore, inclusion of size/mass dependence is indicated for 131I radiotherapy of the thyroid. en_US
dc.language.iso en_US en_US
dc.publisher Institue of physics en_US
dc.subject Natural Science en_US
dc.subject thyroid en_US
dc.subject volume reduction en_US
dc.subject absorbed dose en_US
dc.subject therapy en_US
dc.subject Geant4 Monte Carlo en_US
dc.subject simulation en_US
dc.title Influence of thyroid volume reduction on absorbed dose in 131I therapy studied by using Geant4 Monte Carlo simulation en_US
dc.type Article en_US


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