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BIOMARKERS OF PROSTATE CANCER: A REVIEW

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dc.contributor.author N. Roohi
dc.contributor.author N. Asif
dc.contributor.author H. Ali
dc.date.accessioned 2023-03-14T05:15:47Z
dc.date.available 2023-03-14T05:15:47Z
dc.date.issued 2009-06-08
dc.identifier.citation Hessels, D., & Schalken, J. A. (2013). Urinary biomarkers for prostate cancer: a review. Asian journal of andrology, 15(3), 333. en_US
dc.identifier.issn 0300-9877
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/18939
dc.description.abstract Prostate cancer, an enigma and challenge is the most frequently diagnosed cancer in males in the United States, accounting for an estimated 186,320 new cases in 2008. Most diagnoses are currently being made in patients who have early stages of the disease and no symptoms. The focus has now moved from early detection to determining the clinical significance of these early-stage tumors. The identification of specific prostate cancer biomarkers can have a significant effect on the prognosis, diagnosis and treatment options for patients. Prostate-specific antigen (PSA) and digital rectal exams remain the hallmark assessments for screening individuals for prostate cancer. Genomic¬and proteomic-based studies have led to the identification of a large number of candidate biomarkers, as well as signature patterns of multiple markers for prostate cancer diagnosis, disease progression and prediction of survival. While these candidates include the usual suspects, including oncogenes, proliferation markers and cytoskeletal proteins, there are many additional unexpected molecules involved in processes such as transcriptional repression and fatty acid metabolism. These markers can be measured in serum, tissue or urine samples. Future research should focus on validation of already existing biomarkers and the discovery of new markers to identify men with aggressive prostate cancer. en_US
dc.language.iso en en_US
dc.publisher Lahore: Pakistan Association for the Advancement of Science en_US
dc.subject Prostate cancer en_US
dc.subject biomarkers en_US
dc.title BIOMARKERS OF PROSTATE CANCER: A REVIEW en_US
dc.type Article en_US


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