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OPTIMIZATION OF DIFFERENT PARAMETERS FOR THE PRODUCTION OF BACITRACIN IN SYNTHETIC MEDIUM BY BACILLUS LICHENIFORMIS MUTANT STRAIN UV-MN-HN-8

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dc.contributor.author M. N. Aftab
dc.contributor.author I. U. Haq
dc.contributor.author S. Baig
dc.date.accessioned 2023-03-14T05:26:31Z
dc.date.available 2023-03-14T05:26:31Z
dc.date.issued 2010-06-13
dc.identifier.citation Aftab, M. N. (2010). Optimization of Different Parameters for the Production of Bacitracin in Synthetic Medium by Bacillus Licheniformis Mutant Strain Uv-Mn-Hn-8. Pakistan Journal of Science, 62(2). en_US
dc.identifier.issn 0300-9877
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/18972
dc.description.abstract The present study is focused on the optimization of different parameters for the production of bacitracin using synthetic medium by Bacillus licheniformis UV-MN-HN-8. Maximum bacitracin production was achieved at 37°C. Optimization of incubation time reveals that bacitracin production reached its maximum limit after 48 hours of incubation. At neutral pH, bacitracin production was maximum. Effect of the addition of metal ions, phosphate sources, organic acids, and phosphate sources, inoculum age and size, temperature, pH, incubation time and aeration indicate that Ni+2, KH2PO4, lactic acid, 20 hours old 6% inoculum, 37ºC, pH 7, 48 hours of incubation time and 25 ml medium gave higher yields of bacitracin ((51.3±1.29 IU/ml). On the basis of kinetic variables, notably Yp/s (IU/g substrate), Yp/x (IU/g cells), Yx/s (g/g), Yp/s mutant strain B. licheniformis UV-MNHN-8 was found to be producing 2.33 fold more bacitracin than wild type after optimization of different parameters. en_US
dc.language.iso en en_US
dc.publisher Lahore: Pakistan Association for the Advancement of Science en_US
dc.subject Bacitracin en_US
dc.subject Bacillus licheniformis en_US
dc.subject synthetic medium en_US
dc.subject optimization en_US
dc.subject production en_US
dc.title OPTIMIZATION OF DIFFERENT PARAMETERS FOR THE PRODUCTION OF BACITRACIN IN SYNTHETIC MEDIUM BY BACILLUS LICHENIFORMIS MUTANT STRAIN UV-MN-HN-8 en_US
dc.type Article en_US


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