PASTIC Dspace Repository

BIOEQUIVALENCE OF TWO ORAL FORMULATIONS OF MOXIFLOXACIN AND ITS ANALYTICAL STUDY BY HPLC-UV METHOD

Show simple item record

dc.contributor.author M. Sher
dc.contributor.author M. A. Hussain
dc.contributor.author S. Jahan
dc.contributor.author A. R. Mufti
dc.contributor.author M. A. Shaheen
dc.contributor.author M. N. Hassan
dc.contributor.author Sajid Bashir
dc.date.accessioned 2023-03-14T05:30:57Z
dc.date.available 2023-03-14T05:30:57Z
dc.date.issued 2010-06-14
dc.identifier.citation Sher, M. (2010). Bioequivalence of two oral formulations of moxifloxacin and its analytical study by HPLC-UV method. Pakistan Journal of Science, 62(2). en_US
dc.identifier.issn 0300-9877
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/18981
dc.description.abstract An HPLC-UV method was developed which permits determination, bioequivalence and stability of moxifloxacin in tablets. The chromatographic separation was achieved on C18 column in isocratic mode (methanol, water and acetonitrile 45:30:25) at pH 4 and eluents were detected at 295 nm. After single oral dose (400 mg) of two formulations (Avelox, Bayer and Staxin, Stand Pharma) of moxifloxacin administered to healthy volunteers, pharmacokinetics parameters were derived from the plasma concentrations curves for both formulations. Both of the formulations were bioequivalent on the basis of pharmacokinetic analysis with no adverse reactions of drug were observed. The present method is effective extraction technique with good reproducible recovery and a limit of quantification of 20 ng.ml -1. The method was successfully applied for stability studies of moxifloxacin tablets for six months and has been found stable at accelerated conditions of temperature and relative humidity. en_US
dc.language.iso en en_US
dc.publisher Lahore: Pakistan Association for the Advancement of Science en_US
dc.subject Bioequivalence en_US
dc.subject Bioavailability en_US
dc.subject HPLC en_US
dc.subject Moxifloxacin en_US
dc.subject Pharmacokinetics en_US
dc.subject Stability en_US
dc.title BIOEQUIVALENCE OF TWO ORAL FORMULATIONS OF MOXIFLOXACIN AND ITS ANALYTICAL STUDY BY HPLC-UV METHOD en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account