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THE EFFECTS OF FREE RADICALS ON ANTIOXIDANT DEFENCE SYSTEMS AND ORGANISM IN HEMODIALYSIS PATIENTS

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dc.contributor.author MUSTAFA YONTEM
dc.contributor.author MURAT BILGE
dc.contributor.author SULEYMAN KALELI
dc.contributor.author SEVIL KURBAN
dc.contributor.author GULPERI CELIK
dc.date.accessioned 2023-09-07T07:59:13Z
dc.date.available 2023-09-07T07:59:13Z
dc.date.issued 2011-06-16
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19617
dc.description.abstract Chronic Renal Failure (CRF) is accompanied by a variety of complications which may develop due to an increase in oxidant stress and/or a decrease in antioxidant activities. Hemodialysis (HD) is still the most prevalent method used for the end stage renal failure throughout the world. In this study, it was aimed to research thoroughly whether an increase in lipid peroxidation occurs in hemodialysis patients with advanced CRF and to evaluate antioxidant enzyme activities. Plasma MDA which is the indicator of lipid peroxidation and plasma SOD, CAT, GSH-Px levels as well as total antioxidant status (TAS) values which are the indicators of antioxidant defense systems have been determined in CRF patients who have undergone hemodialysis treatment and in the control group. Compared to those found in the control group, MDA and SOD levels in CRF patient group have statistically increased (p<0,001), while GSH-Px and CAT values have been found to decrease (p<0,001). TAS values have been determined to increase in the control group before the hemodialysis and to decrease after the hemodialysis, which is statistically insignificant. With regard to the correlation calculation we’ve made, a statistically positive correlation have been found between urea and creatinine both pre- and after hemodialysis, while no statistically significance have been recorded among other parameters. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher Karachi: International Centre for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi en_US
dc.title THE EFFECTS OF FREE RADICALS ON ANTIOXIDANT DEFENCE SYSTEMS AND ORGANISM IN HEMODIALYSIS PATIENTS en_US
dc.type Article en_US


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