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THE FAS/FASL PATHWAY MEDIATES APOPTOSIS OF SPLENIC LYMPHOCYTES IN PIGLETS INFECTED WITH PCV2

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dc.contributor.author LIZHONG HUA
dc.contributor.author YUN SUN
dc.contributor.author GENG CHEN
dc.contributor.author SHUXIA ZHANG
dc.date.accessioned 2023-09-07T08:43:52Z
dc.date.available 2023-09-07T08:43:52Z
dc.date.issued 2011-06-17
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19618
dc.description.abstract The aim of this study is to investigate the molecular pathogenetic mechanism of PCV2-induced apoptosis in the porcine spleen. Nineteen piglets were allotted into four groups and sacrificed at 0, 14, 21, or 35 days post inoculation (DPI) with PCV2. PCV2 infection was found to be associated with apoptosis of porcine spleen by flow cytometry, as caspase-3 activity in the spleens of the three experimental groups (14, 21, and 35 DPI) was significantly higher than in the control group (0 DPI) (p<0.01). Expression of the FasL mRNA was upregulated by PCV2 infection, particularly at 21 and 35 DPI. Caspase-8 and caspase-9 activity increased in PCV2 infection was also detected. The concentration of sFas in the serum was decreased at 14 DPI compared to the control group (p<0.05). The data presented here in support the hypothesis that PCV2 induces apoptosis of lymphocytes in the spleens of infected piglets, and that induction of apoptosis is mediated, at least partially, through the Fas/FasL pathway. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher Karachi: International Centre for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi en_US
dc.title THE FAS/FASL PATHWAY MEDIATES APOPTOSIS OF SPLENIC LYMPHOCYTES IN PIGLETS INFECTED WITH PCV2 en_US
dc.type Article en_US


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