Synthesis, Leishmanicidal and Enzyme Inhibitory Activities of Quinoline-4-Carboxylic Acids

Abstract

A series of quinoline4-carboxylic acids 1-13 wæ synthesized and screened for their leishmanicidal, phosphodiesterase, ß•glucuronidase md urease inhibitory properties. Only compounds 3 and 7 were found to be active against leishmaniasis with ICY) values of 76.26 ± 0.71 and 62.86 ± 0.35 pg/mL, respectively. In phosphodiesterase assay only compound 13 showed maximum percentage inhibition (47.2%) among all the tested compounds. Compound 9 showed maximum percentage inhibition value (47.4%) against ß-glucuronidase enzyme. Compound 13 showed maximum percentage inhibition value i.e. 14.10 % against urease enzyme. The structures of all the synthetic compounds were deduced by spectroscopic techniques, including IH NMR, El-MS, IR, and UV spectroscopy.