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Greener Approach to the Synthesis of 4-Thiazolidinone Derivatives Using Phase Transfer Catalysts under Microwave Irradiation

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dc.contributor.author MUHAMMAD NAEEM
dc.contributor.author CHAUDHRY, MUHAMMAD NAWAZ
dc.contributor.author BALOCH, IFTIKHAR HUSSAIN
dc.contributor.author RANA AMJAD
dc.date.accessioned 2023-09-20T04:04:33Z
dc.date.available 2023-09-20T04:04:33Z
dc.date.issued 2009-08-20
dc.identifier.citation Naeem, M., Chuudhary, M. N., & Baloch, I. H. (2009). Greener approach to the synthesis of 4-thiazolidinone derivatives using phase transfer catalysts under microwave irradiation. Journal of the Chemical Society of Pakistan, 31(4), 633-637. en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19664
dc.description.abstract A series of ten newly synthesized compounds are reported by adopting environment friendly microwave irradiation methodology, with an idea that these compounds will be tested for in vitro antibacterial and antifungal activity. In combination to microwave radiation and tributylammonium bromide (TBAB), triethylbenzylammonium chloride (TEBAC) and polyethylene glycol (PEG) were used as phase transfer catalysts in non toxic solvent for reaction activation and TBAB showed better yields. Chromatographic techniques such as Thin Layer Chromatography, Flash Chromatography, Column Chromatography were used for purification and the average yield of all compounds was found to be 76-96 %. Structural elucidation was carried out using FTIR, 1H-NMR, elemental analyzer and MS. The synthesized compounds were checked for their antibacterial activity (in-vivo) and it was found that compounds exhibited different antibacterial activities depending on the nature and position of the substituents on the thiazolidinone ring. The most active compounds 1d, 1i and 1j showed broad spectrum antibacterial activities. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi. en_US
dc.title Greener Approach to the Synthesis of 4-Thiazolidinone Derivatives Using Phase Transfer Catalysts under Microwave Irradiation en_US
dc.type Article en_US


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