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Lead Application for the Stimulation of Fusaricidin Type Compounds by Paenibacillus polymyxa SQR-21

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dc.contributor.author WASEEM RAZA
dc.contributor.author HONGSHENG WU
dc.contributor.author YANGCHUN XU
dc.contributor.author SHEN QIRONG
dc.date.accessioned 2023-09-28T06:33:37Z
dc.date.available 2023-09-28T06:33:37Z
dc.date.issued 2011-04-10
dc.identifier.citation WU, H., QIRONG, S., Xu, Y., & RAZA, W. (2011). Lead application for the stimulation of fusaricidin type compounds by Paenibacillus polymyxa SQR-21. Journal of the Chemical Society of Pakistan, 33(6), 193. en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19730
dc.description.abstract Paenibacillus polymyxa strains produce fusaricidin type compounds that are active against a wide variety of Gram-positive bacteria and fungi. Growth and production of fusaricidin type antifungal compounds by P. polymyxa SQR-21 were compared in tryptone broth supplemented with three concentrations (200, 400 and 600 µM) of lead. The data revealed that the growth of P. polymyxa increased by 7-34 % and fusaricidin type compounds production increased by 15-70 % with the increase in concentration of lead ion (Pb²⁺). The increase in Pb²⁺ concentration, decreased the intracellular carbohydrate contents but increased the intracellular protein and lipid contents, however, higher levels of Pb2+ inhibited the intracellular protein and lipid contents. On the other hand, extracellular protein contents were decreased and extracellular polysaccharide contents were increased with the increase in Pb2+ contents in liquid culture. In addition, the regulatory effects of lead were also reflected by decrease of total RNA and increase of relative expression of the six module-containing nonribosomal peptide synthetase (FusA) when the lead treated experimental samples were compared with the untreated controls. The Pb²⁺ seems to be directly or indirectly correlated with the production of fusaricidin type antifungal compounds. This information will aid in developing fermentation technology for maximum antibiotic production. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher Karachi: The Chemical Society Of Pakistan en_US
dc.title Lead Application for the Stimulation of Fusaricidin Type Compounds by Paenibacillus polymyxa SQR-21 en_US
dc.type Article en_US


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