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On-Line Inhibition Study of Immobilised Acetylcholinesterase by Aqueous Extracts of Momordica charantia (Bitter Melon)

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dc.contributor.author TAHSEEN GHOUS
dc.contributor.author NOSHEEN AZIZ
dc.contributor.author ALMAS ABID
dc.contributor.author AAMIR RASHEED
dc.contributor.author MAZHAR IQBAL
dc.date.accessioned 2023-10-05T03:05:50Z
dc.date.available 2023-10-05T03:05:50Z
dc.date.issued 2010-12-20
dc.identifier.citation Ghous, T., Aziz, N., Abid, A., Rasheed, A., & Iqbal, M. (2010). On-Line Inhibition Study of Immobilised Acetylcholinesterase by Aqueous Extracts of Momordica charantia (Bitter Melon). JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 32(6), 814-818. en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19784
dc.description.abstract Momordica charantia (MC) also known as bitter melon is commonly used as a folk medicine in most parts of South Asia. The role of MC in diabetes is of great importance because it lowers blood sugar and delays diabetic complications. Anti-diabetic activity of MC is relatively well known, literature for its anti-acetylcholinesterase (anti-AChE) activity is rarely available which has provided us a scope to explore its anti-AChE activity. In this study, we have used flow injection (FI) technique with immobilized enzyme column for AChE inhibition study by four different aqueous extracts. Results show that untreated pulp extract (MCPu) with [IC₅₀ = 7.2 mg/mL] acquires stronger anti-AChE activity whereas, MCPt (treated pulp extract) and MCFu (untreated flesh extract) showed almost similar action against AChE activity [IC₅₀ =14 and 15 mg/mL, respectively] while MCFt (treated flesh extract) showed weaker action against AChE activity [IC₅₀ =26 mg/mL]. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi. en_US
dc.title On-Line Inhibition Study of Immobilised Acetylcholinesterase by Aqueous Extracts of Momordica charantia (Bitter Melon) en_US
dc.type Article en_US


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