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Synthesis of Substituted Pyrimidin-4(1H)-one (Uracil) Derivatives and Some of Their Reactions

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dc.contributor.author MOHAMMAD BARMAKI
dc.date.accessioned 2023-10-05T10:00:46Z
dc.date.available 2023-10-05T10:00:46Z
dc.date.issued 2011-12-20
dc.identifier.citation Barmaki, M. (2011). Synthesis of substituted pyrimidin-4 (1H)-one (uracil) derivatives and some of their reactions. Journal of Chemical Society of Pakistan, 33(6), 893-899. en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19796
dc.description.abstract In this paper I described two practical routes for the synthesis of substituted Uracilderivatives and achieved some of their reactions. In the first synthesis which is based on the condensation reaction of ethyl 2- cyanoacetate and thiourea, the cyclized compound 6-amino-2mercaptopyrimidin-4(3H)-one (I) achieved in the presence of sodium ethanoate. Thecompund (I) react with 2-(chloromethyl)oxirane in the given medium (II) was produced, then treated in medium of ethanol in peresence of KOH which new recyclized product 8-amino-3,4-dihydro-3hydroxypyrimido[2,1-b][1,3]thiazin-6(2H)-one (III) was obtained.The other ring closing cyclization proceeded 6-methyl-2,3-dihydro-2-thioxopyrimidin-4(1H)-one (IV) by ethyl acetoacetate and thiourea in ethyl alcohol and potassium hydroxide medium. In the next reaction, firstly Sodium Salt of (V) was gained, then it was reacted with 2-(chloromethyl)oxirane. At the end, substitued derivative (VI) was resulted.All synthesized products were confirmed by IR, ¹H NMR, ¹³C NMR, and elemental analysis. All the experimental data is described extensively in this report. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi. en_US
dc.title Synthesis of Substituted Pyrimidin-4(1H)-one (Uracil) Derivatives and Some of Their Reactions en_US
dc.type Article en_US


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