Abstract:
Vindoline is a major alkaloid from the leaves of Vinca roseus Linn. (Catharanthus roseus G. Don) Apocynaceae. Chemically vindoline lacks physiological activity alone but is contained as the pentacyclic moiety in the antineoplastic agents, vinblastine and vincristine. Synthesis, reactions and determination of vindoline by different methods are reviewed from 1976 to 2010.
