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Molecular Characterization of Hemolysin Gene from a Pakistani Clinical Isolate of Vibrio cholerae

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dc.contributor.author ASIF IQBAL
dc.contributor.author AZIM, MUHAMMAD KAMRAN
dc.date.accessioned 2023-10-06T05:36:15Z
dc.date.available 2023-10-06T05:36:15Z
dc.date.issued 2011-12-20
dc.identifier.citation Iqbal, A., & Azim, M. K. (2011). Molecular characterization of hemolysin gene from a Pakistani clinical isolate of vibrio cholerae. J. Chem. Soc. Pak, 33(6), 935. en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19802
dc.description.abstract Hemolysins comprise an important bacterial exotoxin family. The genome of Vibrio cholerae genome contains several hemolysin genes including thermolabile hemolysin which is thought to be the key virulence factor beside Cholera toxin. Molecular characterization of a thermolabile hemolysin gene from a V. cholerae clinical isolate (termed as “ThermH”) was carried out by PCR amplification followed by DNA sequencing. Alignment of hemolysin sequences revealed five single nucleotide polymorphisms in ThermH compared to Vibrio cholerae El Tor. These SNPs resulted in three missense mutations in the translated sequence of ThermH which might be helpful in genotyping of the V. cholerae. The sequence has been submitted to Genbank under the accession number FJ705057. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi. en_US
dc.title Molecular Characterization of Hemolysin Gene from a Pakistani Clinical Isolate of Vibrio cholerae en_US
dc.type Article en_US


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