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Microbial Transformation of Vanillin Isolated from Melia azedarach to Vanillyl Alcohol followed by Protease Inhibition and Antioxidant Activity

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dc.contributor.author DURRE SHAHWAR
dc.contributor.author MUHAMMAD ASAM RAZA
dc.contributor.author TOQIR ALI
dc.contributor.author VIQAR UDDIN AHMAD
dc.date.accessioned 2023-10-10T04:29:08Z
dc.date.available 2023-10-10T04:29:08Z
dc.date.issued 2011-10-20
dc.identifier.citation Shahwar, D., Raza, M. A., Ali, T., & Ahmad, V. U. (2011). Microbial transformation of vanillin isolated from Melia azedarach to vanillyl alcohol followed by protease inhibition and antioxidant activity. Journal of the Chemical Society of Pakistan, 33(5), 715-719. en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19819
dc.description.abstract Vanillin (1) was isolated from ethanolic extract of Melia azedarach L. and incubated in the culture of Aspergillus niger GC-4, which resulted in vanillyl alcohol (2). The product was identified by mass, ¹H and ¹³C-NMR spectroscopy. Protease inhibition potential was measured using in vitro model, which indicated significant enzyme inhibition activity of vanillyl alcohol (2) as compared to vanillin (1). Compound 1 and 2 were screened for antioxidant activity using phosphomolybdate and diphenyl picrylhydrazyl (DPPH) in vitro model systems. Dose-dependant increase in the antioxidant activity of vanillyl alcohol was observed in phosphomolybdate method, while vanillin was found to be inactive. Vanillyl alcohol showed remarkable decay of the free radicals in the solution of DPPH within first two minutes which finally became constant after five minutes. In contrast, vanillin exhibited much lower antioxidant activity. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi. en_US
dc.title Microbial Transformation of Vanillin Isolated from Melia azedarach to Vanillyl Alcohol followed by Protease Inhibition and Antioxidant Activity en_US
dc.type Article en_US


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