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Anti-bacterial and Anti-leishmanial Studies of 4, 6-diarylpyrimidin-2-amines

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dc.contributor.author MUJAHID HUSSAIN BUKHARI
dc.contributor.author HAMID LATIF SIDDIQUI
dc.contributor.author CHAUDHARY MUHAMMAD ASHRAF
dc.contributor.author TANVIR HUSSAIN
dc.date.accessioned 2023-10-10T04:37:39Z
dc.date.available 2023-10-10T04:37:39Z
dc.date.issued 2011-10-21
dc.identifier.citation Bukhari, M. H., Siddiqui, H. L., Hussain, T., & Ashraf, C. M. (2011). Anti-bacterial and anti-leishmanial studies of 4, 6-diarylpyrimidin-2-amines. Journal of the Chemical Society of Pakistan, 33. en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19820
dc.description.abstract Seven new chalcones along with nine already reported ones were synthesized from aryl aldehydes and substituted acetophenones by Claisen-Schmidt condensation. Each chalcone was treated with guanidine hydrochloride followed by oxidation with H₂O₂ which yielded substituted 4, 6-diarylpyrimidin-2-amines with good to excellent yields. The titled compounds were characterized by spectroscopic techniques (NMR, IR, MS) and elemental analysis. All the compounds were screened for the first time for anti-bacterial and anti-leishmanial activities which exhibited marked biological activity. Compound 4 showed significant activity against E. coli and S. aureus. Compounds 7, 8, 10, 12, 15 and 16 exhibited IC₅₀ values comparable to the standard drug Amphotericin B in anti-leishmanial studies en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi. en_US
dc.title Anti-bacterial and Anti-leishmanial Studies of 4, 6-diarylpyrimidin-2-amines en_US
dc.type Article en_US


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