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The investigation of the Anti-hypercholesterolemic Activities of Thymbra Spicata Labiata Oil (Karabas Thyme Oil) and Atorvastatin

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dc.contributor.author HILAL DEMIRALAY
dc.contributor.author MEHMET. AKDOGAN
dc.contributor.author METIN CIRIS
dc.date.accessioned 2023-10-10T04:48:36Z
dc.date.available 2023-10-10T04:48:36Z
dc.date.issued 2011-10-23
dc.identifier.citation Demiralay, H., Akdogan, M., & Ciris, İ. (2011). The investigation of the anti-hypercholesterolemic activities of Thymbra spicata labiata oil (Karabas Thyme Oil) and Atorvastatin. JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 33(5). en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19822
dc.description.abstract The leaves of TSL (Thymbra Spicata Labiatae), which include plant sterols and stanols, are used in the treatment of hypercholesterolemia, which is a highly prevalent health problem. This study aimed to determine the histopathological effects of TSL oil and atorvastatin (ATS), also known as Karabas thyme, an herb in the Isparta region, on the biochemical parameters and the kidney tissues of the rats who received TSL oil and ATS in varying doses . 42 male four month-old Wistar albino rats with weights ranging from 200 to 250 g were used in this study. They were divided into 6 equal groups with 7 rats in each. The control group was fed standard pellet chow. The cholesterol (Chol) group and the other groups, except control groups, were fed on pellet chow with a cholesterol level of 1%. The 100 TSL, 200 TSL and 300 TSL groups were fed with a gavage tube a mixture of TSL oil, 0.5% Sodium Carboxy Methyl Cellulose (SCMC) of 100, 200 and 300 mg/kg, respectively. On the other hand, a 50 mg/kg Atorvastatin (ATS) 0.5% Sodium Carboxy Methyl Cellulose (SCMC) suspension was prepared and administered with a gavage tube to the 50 ATS group. Control group was given 0.5 ml with probed %0.5 SCMC.30 days later, the experiment was ended, and blood and tissue samples were collected from the rats. The following concentrations were assessed in the blood samples: serum glucose, Blood Urea Nitrogen (BUN), creatine, total protein, albumin, alanine aminotrasferase (ALT), aspartate aminotrasferase (AST), alkaline phosphatase (ALP), creatine kinase (CK), lactate dehydrogenase (LDH), Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-C), High Density Lipoprotein Cholesterol (HDLC), Triglyceride (TG), Oxidized LDL (ox-LDL), fibrinogen, homocysteine, and Vascular Endothelial Growth Factor (VEGF). The kidney tissues were examined histopathologically. It was observed in this study that TSL and ATS did not affect the biochemical test results in general. It was also found that TSL could be influential in hypercholesterolemia and that a 300 mg/kg of TSL and ATS showed an antihypercholesterolemic effect of approximately the same degree. With TSL and ATS, minor kidney defects were observed. However, the effects of TSL increased with larger doses. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi. en_US
dc.title The investigation of the Anti-hypercholesterolemic Activities of Thymbra Spicata Labiata Oil (Karabas Thyme Oil) and Atorvastatin en_US
dc.type Article en_US


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