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Antiproliferative Activity and Chemical Constituents of Hypericum oblongifolium

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dc.contributor.author MUMTAZ ALI
dc.contributor.author MOHAMMAD ARFAN
dc.contributor.author KHAIR ZAMAN
dc.contributor.author HABIB AHMAD
dc.contributor.author NAZIA AKBAR
dc.contributor.author ITRAT ANIS
dc.contributor.author MUHAMMAD RAZA SHAH
dc.date.accessioned 2023-10-12T06:10:44Z
dc.date.available 2023-10-12T06:10:44Z
dc.date.issued 2011-10-29
dc.identifier.citation Ali, M., Arfan, M., Zaman, K., Ahmad, H., Akbar, N., Anis, I., ... & Raza, M. (2011). Antiproliferative activity and chemical constituents of Hypericum oblongifolium. J Chem Soc Pak, 33(5), 772-7. en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19831
dc.description.abstract The antiproliferative activity of hexane (F1), ethyl acetate (F2), butanol (F3) and water (F4) extracts of H. oblongifolium were tested in vitro for their anti- proliferative (anticancer) activity on the cell lines: HT-29 human colon adenocarcinoma, NCI-H460 human non-small cell lung carcinoma, MCF-7 human breast cancer, OVCAR-3 human ovarian adenocarcinoma and RXF-393 human renal cell carcinoma with etoposide as positive control. Among the various extracts the F1 showed relatively potent anti-proliferative activity (10.55 ± 4.19 µg/mL) on OVCAR-3 human ovarian adenocarcinoma cell growth almost equal to the activity of etoposide (9.42 ± 1.62 µg/mL). Seven compounds were also isolated for the first time from this source. These phytochemicals were identified as 18βH-urs-20 (30)-en-3β-ol-28-oic acid (1), tetracosyl 3-(3,4-dihydroxyphenyl) acrylate (2), Shikimic acid (3), 1-Octatriacontanol (4), Hexacosyl tetracosanoate (5), β-Sitosterol (6) and β-Sitosterol3-O-β-D-glucopyranoside (7) on the basis of spectroscopic studies such as 1H NMR ,13C NMR, 2D NMR and Mass spectroscopy as well as established with help of reported literature. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi en_US
dc.title Antiproliferative Activity and Chemical Constituents of Hypericum oblongifolium en_US
dc.type Article en_US


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