dc.contributor.author |
MUMTAZ ALI |
|
dc.contributor.author |
MOHAMMAD ARFAN |
|
dc.contributor.author |
KHAIR ZAMAN |
|
dc.contributor.author |
HABIB AHMAD |
|
dc.contributor.author |
NAZIA AKBAR |
|
dc.contributor.author |
ITRAT ANIS |
|
dc.contributor.author |
MUHAMMAD RAZA SHAH |
|
dc.date.accessioned |
2023-10-12T06:10:44Z |
|
dc.date.available |
2023-10-12T06:10:44Z |
|
dc.date.issued |
2011-10-29 |
|
dc.identifier.citation |
Ali, M., Arfan, M., Zaman, K., Ahmad, H., Akbar, N., Anis, I., ... & Raza, M. (2011). Antiproliferative activity and chemical constituents of Hypericum oblongifolium. J Chem Soc Pak, 33(5), 772-7. |
en_US |
dc.identifier.issn |
0253-5106 |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/19831 |
|
dc.description.abstract |
The antiproliferative activity of hexane (F1), ethyl acetate (F2), butanol (F3) and water (F4) extracts of H. oblongifolium were tested in vitro for their anti- proliferative (anticancer) activity on the cell lines: HT-29 human colon adenocarcinoma, NCI-H460 human non-small cell lung carcinoma, MCF-7 human breast cancer, OVCAR-3 human ovarian adenocarcinoma and RXF-393 human renal cell carcinoma with etoposide as positive control. Among the various extracts the F1 showed relatively potent anti-proliferative activity (10.55 ± 4.19 µg/mL) on OVCAR-3 human ovarian adenocarcinoma cell growth almost equal to the activity of etoposide (9.42 ± 1.62 µg/mL). Seven compounds were also isolated for the first time from this source. These phytochemicals were identified as 18βH-urs-20 (30)-en-3β-ol-28-oic acid (1), tetracosyl 3-(3,4-dihydroxyphenyl) acrylate (2), Shikimic acid (3), 1-Octatriacontanol (4), Hexacosyl tetracosanoate (5), β-Sitosterol (6) and β-Sitosterol3-O-β-D-glucopyranoside (7) on the basis of spectroscopic studies such as 1H NMR ,13C NMR, 2D NMR and Mass spectroscopy as well as established with help of reported literature. |
en_US |
dc.description.sponsorship |
The chemical society of Pakistan is an approved society from the PSF. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
HEJ Research Institute of Chemistry, University of Karachi, Karachi |
en_US |
dc.title |
Antiproliferative Activity and Chemical Constituents of Hypericum oblongifolium |
en_US |
dc.type |
Article |
en_US |