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Determination of Synthetic Phenolic Antioxidants in Cake by HPLC/DAD after Mixed Micelle–Mediated Cloud Point Extraction

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dc.contributor.author Peijin Wang
dc.contributor.author Dongling Meng
dc.contributor.author Chang liu
dc.contributor.author Yaling Yang
dc.date.accessioned 2023-10-19T09:39:43Z
dc.date.available 2023-10-19T09:39:43Z
dc.date.issued 2013-10-20
dc.identifier.citation Wang, P., Meng, D., Liu, C., & Yang, Y. (2013). Determination of Synthetic Phenolic Antioxidants in Cake by HPLC/DAD after Mixed Micellea" Mediated Cloud Point Extraction. Journal of the Chemical Society of Pakistan, 35(5). en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19852
dc.description.abstract A mixed micelle-mediated cloud point extraction (MMCPE) system was developed for the extraction and preconcentration of four synthetic phenolic antioxidants (SPAs) (propyl gallate (PG), tert-butylhydroquinone (TBHQ), butylated hydroxyanisole (BHA) and octyl gallate (OG) ) in cake. The mixture of two kinds of non-ionic surfactants polyoxy ethrlene nonyl phinyl ether (NP-7) and polyoxy ethrlene nonyl phinyl ether (NP-9) was utilized as a suitable micellar medium for preconcentration and extraction of SPAs. The surfactant-rich phase was then analyzed by high performance liquid chromatography-diode array detection (HPLC–DAD). The effect of different parameters such as concentration of surfactants, proportion of NP-7 and NP-9, equilibration time and temperature on the cloud point extraction (CPE) was carefully optimized. Under the studied conditions, four SPAs were successfully separated within 12 min. The relative standard deviations (RSD, n=6) were 1.2–2.0% and the limits of detection (LOD) were 1.5 ng mL₋1 for PG, 3.6 ng mL-1 for TBHQ, 2.9 ng mL-1 for BHA, and 0.8 ng mL-1 for OG, respectively. Recoveries of the SPAs in spiked cake samples were in the range of 92% to 99%. The MMCPE method showed potential advantage for the preconcentration of the SPAs, with enrichment factor of 25. Moreover, the method is simple, has high sensitivity, consumes much less solvent, and has significant advantage in extraction efficiency compared to traditional CPE methods. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi. en_US
dc.subject Cloud-point extraction en_US
dc.subject Mixed micelle en_US
dc.subject , Cake, High-performance liquid chromatography en_US
dc.subject Synthetic phenolic antioxidants en_US
dc.title Determination of Synthetic Phenolic Antioxidants in Cake by HPLC/DAD after Mixed Micelle–Mediated Cloud Point Extraction en_US
dc.type Article en_US


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