Synthesis, Characterization and Antimicrobial Activity of Potential Bioactive Organotin(IV) Dithiocarboxylates

Abstract

A series of newly synthesized organotin(IV) compounds; Me₂SnClL (1) Bu₂SnClL (2), Ph₂SnClL (3), Me₃SnL (4), Ph₃SnL (5) have been derived from the reaction of organotin(IV) chlorides with 4-formylpiperazinium 4-formylpiperazine-1-carbodithioate (L) in the appropriate molar ratio. Their spectroscopic investigations have been carried out in solution state. Based on spectroscopic results, the ligand appeared to coordinate to the Sn atom through the CSS moiety. Bioassay results have revealed that these compounds have good antibacterial and antifungal activities and may well be the basis for a new class of antimicrobial drugs. The triorganotin(IV) derivatives in particular, were found to be more active than diorganotin(IV) compounds.