Vinblastine: A Review

dc.contributor.author	INAM-UL.-HAQUE
dc.contributor.author	HINA SARA
dc.date.accessioned	2023-10-31T05:24:32Z
dc.date.available	2023-10-31T05:24:32Z
dc.date.issued	2010-04-19
dc.identifier.citation	Kumar, A. S. H. U. T. O. S. H. (2016). Vincristine and vinblastine: a review. IJMPS, 6, 23-30.	en_US
dc.identifier.issn	0253-5106
dc.identifier.uri	http://142.54.178.187:9060/xmlui/handle/123456789/19894
dc.description.abstract	Vinblastine sulfate extracted from leaves of Catharanthus roseus is widely used as an anti-cancer drug. Chemically vinblastine is one of the Vinca alkaloids that inhibit the polymerization of tubulin, resulting in the disappearance of the microtubular spindle, and as a consequence they cause the arrest of cell division in their metaphase. There is limited information in the literature on the metabolism of vinblastine. 4-Deacetylvinblastine has been reported to be a urinary metabolite of vinblastine in dog and in humans. Determination and detection of vinblastine sulfate and its metabolites, by different methods, in biological samples is reviewed from 1972 to 2009.	en_US
dc.description.sponsorship	The chemical society of Pakistan is an approved society from the PSF.	en_US
dc.language.iso	en	en_US
dc.publisher	HEJ Research Institute of Chemistry, University of Karachi, Karachi.	en_US
dc.title	Vinblastine: A Review	en_US
dc.type	Article	en_US