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Application of Multi-Walled Carbon Nanotubes Modified Glassy Carbon Electrode for Determination of Mefenamic Acid in Pharmaceutical Preparations and Biological Fluids

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dc.contributor.author MOHAMMAD AFRASIABI
dc.contributor.author SHOKAT KIANIPOUR
dc.contributor.author ZEINAB REZAYATI ZAD
dc.contributor.author ALI BABAEI
dc.date.accessioned 2023-11-17T10:02:24Z
dc.date.available 2023-11-17T10:02:24Z
dc.date.issued 2013-08-08
dc.identifier.citation Branch, S. (2013). Application of multi-walled carbon nanotubes modified glassy carbon electrode for determination of mefenamic acid in pharmaceutical preparations and biological fluids. J. Chem. Soc. Pak, 35(4), 1113. en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19953
dc.description.abstract A chemically modified electrode is constructed based on multi-walled carbon nanotube modified glassy carbon electrode (MWCNTs/GCE). It is demonstrated that this sensor could be used for determination of pharmaceutically important compound mefenamic acid (MEF). Differential pulse voltammetry (DPV) experiments of various concentration of MEF showed two linear dynamic ranges. The first linear dynamic range was from 2 μM to 40 μM, and the second linear dynamic range was between 50 μM to 360 μM. A detection limit of 0.21 µM (S/N = 3) was obtained. Under optimal conditions the modified electrode exhibited high sensitivity and stability for determination of MEF, making it a suitable sensor for the submicromolar detection of MEF in solutions. The analytical performance of this sensor has been evaluated for the detection of MEF in human serum, human urine and a pharmaceutical preparation with satisfactory results. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi. en_US
dc.subject Electrode en_US
dc.subject MWCNTs/GCE en_US
dc.subject Mefenamic acid en_US
dc.subject Differential Pulse Voltammetry en_US
dc.subject Serum en_US
dc.title Application of Multi-Walled Carbon Nanotubes Modified Glassy Carbon Electrode for Determination of Mefenamic Acid in Pharmaceutical Preparations and Biological Fluids en_US
dc.type Article en_US


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