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Synthesis and In vitro Antioxidant Activities of Novel 4-(3-methyl-2-thienylmethyleneamino)-4,5-dihydro-1H-1,2,4-triazol-5-one Derivatives with Their Acidic Properties

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dc.contributor.author OZLEM GURSOY KOL
dc.contributor.author HAYDAR YUKSEK
dc.contributor.author FATIH ISLAMOGLU
dc.date.accessioned 2023-11-21T04:42:07Z
dc.date.available 2023-11-21T04:42:07Z
dc.date.issued 2013-08-03
dc.identifier.citation Kol, O. G., Yuksek, H., & Islamoglu, F. (2013). Synthesis and in vitro antioxidant activities of novel 4-(3-methyl-2-thienylmethyleneamino)-4-5-dihydro-1H-1, 2, 4-triazol-5-one derivatives with their acidic properties. Journal of the Chemical Society of Pakistan, 35(4), 1179-1190. en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19961
dc.description.abstract In the present study 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2a-i reacted with 3-methyl-thiophene-2-carboxyaldehyde to afford the corresponding 3-alkyl(aryl)-4-(3-methyl-2-thienylmethyleneamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 3a-i. The acetylation reactions of compounds 3a, 3b, 3d, 3g and 3i were investigated and compounds 4a, 4b, 4d, 4g and 4i were thus obtained. The structures of fourteen new compounds are established from the spectral data. In addition, the synthesized 3 and 4 type compounds were analyzed for their in vitro potential antioxidant activities in three different methods including reducing power, free radical scavenging and metal chelating activity. Compound 3a and 3d showed the best activity for the iron binding. On the other hand, compounds 3a-i were titrated potentiometrically with tetrabutylammonium hydroxide (TBAH) in four nonaqueous solvents (isopropyl alcohol, t-butyl alcohol, acetonitrile and N,N-dimethylformamide) because of the weak acidic properties of 4,5-dihydro-1H-1,2,4-triazol-5-one ring N-H group. Also half-neutralization potential (HNP) values and the corresponding pKa values were determined in all cases. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi. en_US
dc.subject 1,2,4-Triazol-5-one en_US
dc.subject Schiff base en_US
dc.subject Synthesis en_US
dc.subject Antioxidant activity en_US
dc.subject Acidity en_US
dc.subject Potentiometric titrations en_US
dc.title Synthesis and In vitro Antioxidant Activities of Novel 4-(3-methyl-2-thienylmethyleneamino)-4,5-dihydro-1H-1,2,4-triazol-5-one Derivatives with Their Acidic Properties en_US
dc.type Article en_US


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