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Effects of Dimenhydrinate, Prochlorperazine and Cyclizine on Thyroid Hormones and FSH in Sera of Normal Male Rabbits

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dc.contributor.author AHMAD
dc.contributor.author KHALID HUSSAIN JANBAZ
dc.contributor.author SAEED AHMAD
dc.contributor.author GHULAM ABBAS
dc.date.accessioned 2023-12-01T04:21:40Z
dc.date.available 2023-12-01T04:21:40Z
dc.date.issued 2010-06-13
dc.identifier.citation Ahmad, Janbaz, K. H., Ahmad, S., & Abbas, G. (2010). Effects of Dimenhydrinate, Prochlorperazine and Cyclizine on Thyroid Hormones and FSH in Sera of Normal Male Rabbits. JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 32(3), 344-348. en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19986
dc.description.abstract The effects of dimenhyrinate, prochlorperazine and cyclizine on the serum thyroid hormones and follicle stimulating hormone levels were studied in normal male rabbits for 14-days. Dimenhyrinate (Group B) and cyclizine (Group D) were given intramuscularly 10 mg and prochlorperazine (Group C) 5 mg / kg body weigh / day. Serum was collected at zero, 7 and 14 days and assays were carried out using standard methods. Results show a significant decrease (p< 0.05) in all the parameters measured at 14-day compared with the control group (Group A) except the effect of dimenhydrinate on T4 levels wherein it remained unchanged. It is speculated from these results that hypothalamus and pituitary gland functioning is affected by these drugs through modulation of neurotransmitters in CNS which results in significant decrease in serum T4, T3 and FSH levels. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi en_US
dc.title Effects of Dimenhydrinate, Prochlorperazine and Cyclizine on Thyroid Hormones and FSH in Sera of Normal Male Rabbits en_US
dc.type Article en_US


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