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Comparative Study on the Antioxidant and Antimicrobial Activities of Stem-Bark Extract of Litchi chinensis and its Organic Fractions

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dc.contributor.author DURRE SHAHWAR
dc.contributor.author MUHAMMAD ASAM RAZA
dc.contributor.author MIRZA ABID SHABBIR MUGHAL
dc.contributor.author MUHAMMAD ATHAR ABBASI
dc.contributor.author VIQAR U ODIN AHMAD
dc.date.accessioned 2023-12-01T04:37:06Z
dc.date.available 2023-12-01T04:37:06Z
dc.date.issued 2010-06-16
dc.identifier.citation Shahwar, D., Raza, M. A., Mughal, M. A. S., Abbasi, M. A., & Ahmad, V. U. (2010). Comparative study on the antioxidant and antimicrobial activities of stem-bark extract of Litchi chinensis and its organic fractions. Journal of the Chemical Society of Pakistan, 32(3), 357-362. en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/19989
dc.description.abstract Aqueous-methanolic (20:80) extract of stem-bark of Litchi chinensis Sonn. was fractionated with diethyl ether, ethyl acetate and n-butanol using solvent extraction technique, and then total phenols (TP), total flavonoides (TF) and total condensed tannins (TCT) were calculated for this extract and its organic fractions. Total phenolic compounds ranged from 145.2±1.3 – 680.3±1.2 mg GAE/g of sample, while total flavonoides and total condensed tannins ranged from 101.5±1.4 – 210.4±2.0 mg equivalent to catechin /g of sample and 95.7±1.2 – 324.5±0.8 mg equivalent to catechin/g of sample respectively. Antioxidant potential of the extract and its fractions was evaluated using DPPH radical scavenging and phosphomolybdate assays. Ethyl acetate fraction scavenged maximum DPPH radical (78%, IC₅₀= 15.3 µg/ml), close to BHT (80%, IC₅₀ = 12.4 µg/ml) while aqueous-methanolic extract showed the highest total antioxidant activity (1.09) as compared to its fractions relative to gallic acid. Agar well diffusion assay was also carried out to check the antibacterial activity against six different bacterial strains (Proteus mirabilis, Micrococcus luteus, Bacillus licheniformis, Nocardia asteroids, Salmonella typhimorium and Bacillus subtilis). The aqueous-methanolic extract showed the maximum growth inhibition (19.7±0.9 mm, MIC = 1.2 mg/ml) against Bacillus subtilis. These results suggested the potential use of Litchi extracts as an antioxidant as well as antibacterial agent. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi. en_US
dc.title Comparative Study on the Antioxidant and Antimicrobial Activities of Stem-Bark Extract of Litchi chinensis and its Organic Fractions en_US
dc.type Article en_US


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