dc.contributor.author |
MUHAMMAD KHURRAM SHAHZAD |
|
dc.contributor.author |
MAHBOOB-E-RABBANI |
|
dc.contributor.author |
ASADULLAH MADNI |
|
dc.contributor.author |
MAHMOOD AHMAD |
|
dc.contributor.author |
MUHAMMAD USMAN |
|
dc.contributor.author |
MAHTAB AHMAD KHAN |
|
dc.contributor.author |
HASSAN AHMAD |
|
dc.contributor.author |
MD EKWAL |
|
dc.date.accessioned |
2023-12-22T04:21:37Z |
|
dc.date.available |
2023-12-22T04:21:37Z |
|
dc.date.issued |
2012-06-20 |
|
dc.identifier.citation |
Shahzad, M. K., Ahmad, A. M. M., Akhtar, N., Usman, M., Uzair, M., Khan, M. A., & Ahmad, H. (2012). Characterization and In-Vitro Release Study of Celecoxib Microspheres Synthesized from Polymethacrylate and Polyvinyl Pyrolidone. Journal of the Chemical Society of Pakistan, 34(3). |
en_US |
dc.identifier.issn |
0253-5106 |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/20034 |
|
dc.description.abstract |
The aim of the present study was to formulate and characterize microspheres of celecoxib for controlled delivery. Celecoxib controlled release microspheres were prepared by solvent evaporation technique and were evaluated for physical characteristics and In-Vitro release profile. Drug was entrapped into microspheres of biodegradable polymers Polymethacrylate (PMA) and Poly-Vinyl Pyrrolidone-K30 (PVP) at different ratios. Microsphere recovery decreased with increasing the concentration of PVP in the formulations. Entrapment efficiency of the drug in microspheres increased with decreasing PMA and increasing PVP concentrations. Micrometric properties showed free flowing nature of microspheres. In-Vitro dissolution studies showed pHdependent nature of the microspheres. Under acidic environment (pH 1.2) almost 11–19% of drug was released in first 2 hrs. Almost all of the formulations of microspheres showed a sustained release behavior up to 12 hrs (pH of 6.8). Drug release kinetics followed zero order at pH 1.2 while at pH 6.8 Higuchi model was best fitted. |
en_US |
dc.description.sponsorship |
The chemical society of Pakistan is an approved society from the PSF. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
HEJ Research Institute of Chemistry, University of Karachi, Karachi. |
en_US |
dc.subject |
Celecoxib; Controlled release |
en_US |
dc.subject |
Biodegradable |
en_US |
dc.subject |
Higuchi model |
en_US |
dc.subject |
Microsphere |
en_US |
dc.title |
Characterization and In-Vitro Release Study of Celecoxib Microspheres Synthesized from Polymethacrylate and Polyvinyl Pyrolidone |
en_US |
dc.type |
Article |
en_US |