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Characterization and In-Vitro Release Study of Celecoxib Microspheres Synthesized from Polymethacrylate and Polyvinyl Pyrolidone

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dc.contributor.author MUHAMMAD KHURRAM SHAHZAD
dc.contributor.author MAHBOOB-E-RABBANI
dc.contributor.author ASADULLAH MADNI
dc.contributor.author MAHMOOD AHMAD
dc.contributor.author MUHAMMAD USMAN
dc.contributor.author MAHTAB AHMAD KHAN
dc.contributor.author HASSAN AHMAD
dc.contributor.author MD EKWAL
dc.date.accessioned 2023-12-22T04:21:37Z
dc.date.available 2023-12-22T04:21:37Z
dc.date.issued 2012-06-20
dc.identifier.citation Shahzad, M. K., Ahmad, A. M. M., Akhtar, N., Usman, M., Uzair, M., Khan, M. A., & Ahmad, H. (2012). Characterization and In-Vitro Release Study of Celecoxib Microspheres Synthesized from Polymethacrylate and Polyvinyl Pyrolidone. Journal of the Chemical Society of Pakistan, 34(3). en_US
dc.identifier.issn 0253-5106
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/20034
dc.description.abstract The aim of the present study was to formulate and characterize microspheres of celecoxib for controlled delivery. Celecoxib controlled release microspheres were prepared by solvent evaporation technique and were evaluated for physical characteristics and In-Vitro release profile. Drug was entrapped into microspheres of biodegradable polymers Polymethacrylate (PMA) and Poly-Vinyl Pyrrolidone-K30 (PVP) at different ratios. Microsphere recovery decreased with increasing the concentration of PVP in the formulations. Entrapment efficiency of the drug in microspheres increased with decreasing PMA and increasing PVP concentrations. Micrometric properties showed free flowing nature of microspheres. In-Vitro dissolution studies showed pHdependent nature of the microspheres. Under acidic environment (pH 1.2) almost 11–19% of drug was released in first 2 hrs. Almost all of the formulations of microspheres showed a sustained release behavior up to 12 hrs (pH of 6.8). Drug release kinetics followed zero order at pH 1.2 while at pH 6.8 Higuchi model was best fitted. en_US
dc.description.sponsorship The chemical society of Pakistan is an approved society from the PSF. en_US
dc.language.iso en en_US
dc.publisher HEJ Research Institute of Chemistry, University of Karachi, Karachi. en_US
dc.subject Celecoxib; Controlled release en_US
dc.subject Biodegradable en_US
dc.subject Higuchi model en_US
dc.subject Microsphere en_US
dc.title Characterization and In-Vitro Release Study of Celecoxib Microspheres Synthesized from Polymethacrylate and Polyvinyl Pyrolidone en_US
dc.type Article en_US


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