Abstract:
In vitro permeation studies were done using modified Franz diffusion cell through rabbit
skin and silicone membrane utilizing different ratios of oleic acid with diclofenac diethylamine
(DDA) in normal saline and methanol mixture during present study. Solubility studies indicated
linear increase in drug solubility with carrier concentration. The enhancing effect of all the
enhancer’s ratios was found to be significantly greater than that of standard without enhancer
(control). ‘Benchmark’ values with which to compare the performance of the vehicle are the flux
values which were statistically no significant difference (P>0.05) across rabbit skin and silicone
membrane. The input-rate values of all the ratios have shown a constant trend. The vehicles used
were predominantly influencing the partition of the drug into the skin rather than the diffusion
throughout the study. Consequently, changes in diffusion and/or partition may occur as a result of
absorption or depletion of permeation enhancer inside the membrane/or skin over time which
validates our results.
