PASTIC Dspace Repository

Improving the methotrexate loading/release of magnetite by coating with silica of various thicknesses

Show simple item record

dc.contributor.author Waseem, Muhammad
dc.contributor.author Aleem, Awais
dc.contributor.author Hussain, Rafaqat
dc.contributor.author Hussain, Shahzad
dc.contributor.author Rana, Naveed
dc.contributor.author Saeed, Shaukat
dc.date.accessioned 2019-12-24T06:10:36Z
dc.date.available 2019-12-24T06:10:36Z
dc.date.issued 2019-11-13
dc.identifier.issn 6 125401
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/2055
dc.description.abstract The stability of magnetite nanoparticles can be improved by coating with inert, biocompatible and non-toxic materials. The coated magnetite nanoparticles are the potential candidates for drug delivery, cancer treatment and MRI. In the present study, magnetite nanoparticles (MNPs) were synthesized by co-precipitation, while silica-coated magnetite nanoparticles (SMNPs) of various thicknesses were prepared by oil in water (o/w) microemulsion method. The concentration of sodium silicate (silica precursor) was taken in w/w with respect to MNPs. The size and shape of the MNPs and SMNPs were analyzed by field emission scanning electron microscopy (FESEM) equipped with an energy dispersive X-rays (EDX) spectroscopy, transmittance electron microscopy (TEM), X-rays diffraction (XRD) and dynamic light scattering (DLS). The surface functional groups were detected by using Fourier-transform infrared (FTIR) spectroscopy. The magnetic properties were measured in vibrating sample magnetometer (VSM) and a decrease in the magnetization was noted by increasing the thickness of silica coating around MNPs. Finally, the MNPs and SMNPs of various thicknesses were loaded with anticancer drug methotrexate (MTX) and the release study was monitored by dialysis method. The MNPs have shown a burst release of MTX whereas a sustained drug release was noted for SMNPs of various thicknesses. Among silica coated MNPs, 2 times silica-coated magnetite (2SMNPs) displayed a more sustained drug release. The work presented here therefore, describes a facile and convenient method to fabricate silica coated magnetite nanoparticles for the potential use in the drug delivery systems. en_US
dc.language.iso en_US en_US
dc.publisher Materials Research Express en_US
dc.subject Natural Science en_US
dc.subject methotrexate loading/release en_US
dc.subject magnetite en_US
dc.subject silica en_US
dc.subject thicknesses en_US
dc.title Improving the methotrexate loading/release of magnetite by coating with silica of various thicknesses en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account