Abstract:
This research work was planned to synthesize and characterize transition metal
complexes of some biologically active Schiff base chelating agent and then to investigate
their antimicrobial and antioxidant activities. The ligands (L1-L5) are the modified forms
of pyridine-3-carbaldehyde containing azomethine linkage which is of considerable
importance in coordination chemistry. All the ligands were synthesized by reacting
pyridine-3-carbaldehyde with primary amines. The structure of the newly synthesized
amines were established by IR, NMR, Mass and elemental analysis. The ligands formed
complexes of the type [MLX 2 ]. The comparison of the IR spectra of ligands and their
metal complexes suggested that pyridine-3-carbaldehyde-N and amine-N are involved in
the coordination with the metal ions. The UV-visible spectra of the complexes indicated
the tetrahedral geometry for Co(II), Ni(II), Cu(II) and Zn(II) complexes. The antibacterial
and antifungal activities of all the compounds were tested against the gram negative
bacteria Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa, gram positive
bacteria
Bacillus
subtilis,
Staphylococcus
aureus,
Staphylococcus
epidermidis,
Streptococcus pneumonia and fungal strains Aspergillus Fumigatus, Aspergillus Flavus
and Fusarium Solani. Antioxidant activities including Free Radical Scavenging Assay,
Nitric Oxide Scavenging Activity, Hydroxyl Radical (OH) Scavenging Activity and
Reducing Power were also carried out. Thermal stability of the compounds was studied
through TG/DTA.
